While we don't know much about 2022's She-Hulk show, we have just gotten a report on the main antagonist of the show and their casting. The Good Place star Jameela Jamil has been reported to have joined the cast of Disney Plus’ She-Hulk as the villain Titania.
The news was broken by The Illumenerdi recently and we also have a description of the character. She is described as a social media influencer with a dark side.
UPDATE: Variety has now confirmed the story.
She-Hulk, Starring Tatiana Maslany, Mark Ruffalo, Tim Roth and Jameela Jamil comes out in 2022.